Role of Matrix Metalloproteinases in Angiogenesis and Cancer

By Saray Quintero-Fabián, Rodrigo Arreola, E. Becerril-Villanueva, J. Torres-Romero, V. Arana-Argáez, J. Lara-Riegos, M. Ramírez-Camacho, M. Álvarez-Sánchez. Frontiers in Oncology, 2019

883 citations recorded by the source corpus.

During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the extracellular matrix (ECM), followed by endothelial cell migration, and proliferation and the new generation of matrix components. Matrix metalloproteinases (MMPs) participate in the disruption, tumor neovascularization, and subsequent metastasis while tissue inhibitors of metalloproteinases (TIMPs) downregulate the activity of these MMPs. Then, the angiogenic response can be directly or indirectly mediated by MMPs through the modulation of the balance between pro- and anti-angiogenic factors. This review analyzes recent knowledge on MMPs and their participation in angiogenesis.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/c5f4f089a7e7a66bee0e76a94eb44769876c8b68

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In Cancer Research

1. Huanhuan Chen
2. Li-li Zheng
3. Zhenling Liu
4. Li-Ping Sun
5. Lei Shi

In Molecular Biology

1. Huanhuan Chen
2. Li-li Zheng
3. Zhenling Liu
4. Li-Ping Sun
5. Lei Shi

Citations in the corpus

• Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “EMT is a process in which the transition of epithelial cells to mesenchymal migratory phenotypes,(333) involves the degradation of ECM and basement membrane and the destruction of adhesion in cell-cell or cell-matrix.(322) Actually, the expression level of MMPs is maintained in a dynamic balance und”