Big Effects from Small Changes: Possible Ways to Explore Nature's Chemical Diversity

By H. Bode, B. Bethe, R. Höfs, A. Zeeck. ChemBioChem, 2002

1,078 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/c2c3a1b5bdb86cba3e57e0d33369a91eacb7f19f

How researchers see this paper

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In Molecular Biology

1. D. Kurtböke
2. Amberlee Marker
3. A. Aly
4. O. Kayser
5. A. Debbab
6. P. Proksch
7. C. Brinkmann
8. K. Selim

In Pharmacology

1. K. Selim
2. P. Proksch
3. A. Debbab
4. A. Aly
5. O. Kayser
6. P. Kusari
7. S. Kusari
8. M. Spiteller

Citations in the corpus

• Mycotoxins, drugs and other extrolites produced by species in Penicillium subgenus Penicillium (2004, background): “production All isolates and species in Penicillium subgenus Penicillium produced a large number of different extrolites, thus following the so-called OSMAC (one strain/many compounds) approach (Schiewe and Zeeck, 1999; Bull et al., 2000; Bode et al., 2002).”
• Fungal endophytes: unique plant inhabitants with great promises (2011, background): “Secondary metabolite profiles of fungal species are known to be greatly influenced by varying culture parameters, such as composition of growth medium, aeration, pH, and the presence of certain enzyme inhibitors ( Bode et al. 2002 ).”
• Biology of Endophytic Fungi (2012, background): “…organisms that are well known for producing many novel metabolites which are directly used as drugs or function as lead structures for synthetic modifications (Kock et al. 2001, Bode et al. 2002, Donadio et al. 2002, Chin et al. 2006, Gunatilaka 2006, Mitchell et al. 2008, Stadler & Keller 2008).”
• Endophytic fungi harbored in Cannabis sativa L.: diversity and potential as biocontrol agents against host plant-specific phytopathogens (2013, methodology): “However, random screening of endophytes in axenic cultures often leads to rediscovery of known natural products, with a very high possibility of the ‘cryptic’ bioactive molecules not produced under normal lab conditions (Bode et al. 2002; Scherlach and Hertweck 2009).”
• New ochratoxin A producing species of Aspergillus section Circumdati (2004, background): “…& Mantle 2001b), while A. westerdijkiae and A. ochraceus produce among several other extrolites circumdatins = asperloxins (Rahbaek et al. 1999, Dai et al. 2001) and aspergamides (Fenical et al. 2000, Sugie et al. 2001, Bode et al. 2002, QianCutrone et al. 2002), in addition to the known toxins.”
• Mycotoxin producers in the Aspergillus genus: An update (2015, background): “Bode et al. (2002) clarified that using different media or altering other growth parameters (temperature, water activity, etc.) various exometabolites could be identified in A. westerdijkiae and other fungi.”
• An Overview on Marine Sponge-Symbiotic Bacteria as Unexhausted Sources for Natural Product Discovery (2017, background): “Sound understanding of the ecology [33,91] and functional diversity of marine symbionts [257], in particular those associated with sponges [83], and correlating such understanding with the rationale of symbiont-aided host bioactive metabolite production in marine environments will improve prospects ”
• Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon (2016, background): “Altering the culturing conditions increases the metabolomic diversity available to these organisms, and has been termed the ‘‘one strain, many compounds’’ (OSMAC) approach (Bode et al. 2002).”