Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated.

By A. Zobel, T. Nickel, H. Künzel, N. Ackl, A. Sonntag, M. Ising, F. Holsboer. Journal of Psychiatric Research, 2000

688 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism, Social Psychology

View Paper: https://www.semanticscholar.org/paper/c2aac4c846f34ae622316c79b4e42edf45146443

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Citations in the corpus

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. (2001, background): “The antidepressant and anxiolytic properties of the selective CRF 1 receptor antagonist R121919 was recently demonstrated in a clinical trial of depressed patients (Zobel et al 2000).”
The Corticosteroid Receptor Hypothesis of Depression (2000, background): “After cessation of long-term treatment, patients with depression may have upregulated CRH1 receptors and accumulated ligand (CRH), which together may increase liability for relapse, possibly making tapering of the drug necessary (Zobel et al. 2000).”
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System (2008, background): “Pharmacological activation of CRF produces conditioned place aversion (CPA) in rodents (Cador et al.,1992), and CRF receptor antagonists act as anti-depressants in humans (Zobel et al., 2000).”
The Neurobiology of Parental Behavior (2003, background): “Motivational Models of Maternal Behavior and Aggression CRF by neurons in brain circuits that regulate anxiety-related behavior, since Walker et al. (2001) have reported that CRF mRNA levels in the amygdala are lower in lactating rats than in virgins.”
Neurobiological and psychiatric consequences of child abuse and neglect. (2010, background): “One open, uncontrolled clinical trial in depression has been published (Zobel et al., 2000) and was positive.”
Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives (2009, background): “Based on this, there has been a major effort to develop CRF1 antagonists both as anti-anxiety and antidepressant medicines (Zoebel et al., 2000), but this effort has been plagued by ongoing major difficulties with side effects, particularly hepatotoxicity.”
Discovering Endophenotypes for Major Depression (2004, background): “…and behavioral alterations that resemble the symptoms of major depression including decreased appetite, disrupted sleep, decreased libido, and psychomotor alterations (Nemeroff, 1996); and anxiety and depression scores have been reduced following CRH-1 receptor blockade (Zobel et al, 2000).”