Relationship between Secondary Metabolism and Fungal Development

By A. M. Calvo, R. Wilson, J. Bok, N. Keller. Microbiology and Molecular Biology Reviews, 2002

1,090 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Plant Science

View Paper: https://www.semanticscholar.org/paper/c254e70f7c715bfeb358c4ec2ed6ca02a19030d3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. N. Keller
2. A. Aly
3. A. Debbab
4. P. Proksch
5. Matthew E. Smith
6. J. Bennett
7. R. Upchurch
8. T. Henkel

In Pharmacology

1. P. Proksch
2. A. Debbab
3. A. Aly
4. N. Keller
5. Matthew E. Smith
6. J. Bennett
7. G. Turner
8. E. Ghisalberti

In Plant Science

1. F. Vinale
2. S. Woo
3. T. Henkel
4. J. Rollins
5. R. Marra
6. M. Lorito
7. P. Frey-Klett
8. Matthew E. Smith

Citations in the corpus

• Fungal endophytes: unique plant inhabitants with great promises (2011, background): “Examples include the promotion of vegetative growth and repression of sexual/asexual development, as well as sterigmatocystin production in Aspergillus nidulans, and aflatoxin production in Aspergillus flavus and Aspergillus parasiticus by signaling of the α subunit of a heterotrimeric G-protein, Fa”
• Bacterial-Fungal Interactions: Hyphens between Agricultural, Clinical, Environmental, and Food Microbiologists (2011, background): “In addition to its effects on microbial growth, environmental pH can also influence other microbial processes; for example, the rate of synthesis of the secondary metabolite aflatoxin by Aspergillus parasiticus is higher under acidic growth conditions, while alkaline medium increases the production ”
• Fungal secondary metabolism — from biochemistry to genomics (2005, background): “The correlation of secondary metabolism with fungal development has recently been reviewe”
• Unlocking the Secrets Behind Secondary Metabolism: A Review of Aspergillus flavus from Pathogenicity to Functional Genomics (2003, background): “Much of the work on this pathway has been conducted in A. nidulans, but it is clear that the regulatory mechanisms are conserved in A. flavus and A. parasiticus (Calvo et al., 2002; Guzmán-de-Peña and Ruiz-Herrera, 1997; Hicks et al., 1997).”
• A novel role for Trichoderma secondary metabolites in the interactions with plants (2008, background): “Do to chemical and biological properties of such compounds, they are widely used for medical, pharmaceutical, or agricultural purposes [2].”
• Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products (2010, background): “For example, signaling by the α subunit of a heterotrimeric G-protein, FadA, was found to promote vegetative growth and repress sexual/asexual development, sterigmatocystin production in Aspergillus nidulans, as well as aflatoxin production in A. flavus and A. parasiticus (Calvo et al. 2002).”
• How many fungi make sclerotia (2015, background): “Since different fungi use unique suites of compounds for chemical defense and nutrient storage (Antibus, 1989; Calvo et al., 2002; Li and Rollins, 2010; Zheng et al., 2010), sclerotium-forming fungi are excellent targets for the discovery of antibacterial, antifungal, and anti- herbivore compounds.”
• Host-derived lipids and oxylipins are crucial signals in modulating mycotoxin production by fungi (2009, background): “phytic acid, host proteins, starch, and sugar (for more details, see Zaika and Buchanan, 1987; Calvo et al., 2002; Cleveland et al., 2004; Holmes et al., 2008).”
• Fatty acid unsaturation, mobilization, and regulation in the response of plants to stress (2008, background): “parasiticus in culture, whereas down stream 18:3-derived intermediates hydroperoxylinoleic acid derivatives and other oxylipins (Tsitsigiannis and Keller 2007) inhibit or stimulate aflatoxin production (Calvo et al. 2002).”
• LaeA, a Regulator of Secondary Metabolism in Aspergillus spp (2004, background): “However, all of the signal transduction mutants described in the literature have pleiotropic effects on fungi, the most notable effect being the gross impact on spore production and vegetative hyphal growth (1, 9, 18, 29).”
• Aflatoxins in aquatic species: metabolism, toxicity and perspectives (2008, background): “2002), their biosynthesis and metabolism (Calvo et al. 2002), toxicology and biological effects (Coulombe 1993; Coulombe 1994; Cullen and Newberne 1994; Eaton and Gallagher 1994; Eaton and Groopman 1994), no review has focused on the impact of aflatoxins in aquacultured aquatic species.”
• Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites (2014, background): “The numbering of the amino acids in the CsA molecule corresponds to the order in which each residue was identified by sequential Edman degradation [2].”