Reactive Astrocytes in Neural Repair and Protection

By M. Sofroniew. The Neuroscientist, 2005

797 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/c2310dfaa1cd901ceb81b87969b41958103d7258

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Sofroniew
2. M. Pekny
3. J. Burda
4. M. Pekna
5. E. Hol
6. Y. Ao
7. B. Song
8. Jingwei Qi

In Developmental Neuroscience

1. M. Sofroniew
2. M. Pekny
3. M. Pekna
4. J. Burda
5. E. Hol
6. Y. Ao
7. B. Song
8. Mark A. Anderson

In Neurology

1. M. Sofroniew
2. M. Pekny
3. M. Pekna
4. J. Burda
5. E. Hol
6. Y. Ao
7. B. Song
8. Mark A. Anderson

Citations in the corpus

• Reactive gliosis and the multicellular response to CNS damage and disease (2014, positive): “One efficient means of doing so would be to isolate small focal injuries or small infections with cellular barriers that effectively wall off these lesions, allowing a robust inflammatory (and antimicrobial) responses in lesion cores, while preserving as much adjacent neural tissue as possible (Sofr”
• Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain (2008, background): “However, these proteins are contained in some reactive glial cells, some of which also proliferate (2, 8, 29, 30), and in more immature glia such as radial glia and postnatal glial progenitors, which also proliferate (13, 27, 31).”
• STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury (2008, methodology): “Nevertheless, it is important to note that although reactive astrocyte activities can in some cases be associated with restricting inflammation, limiting lesion size and preserving function (Sofroniew, 2005; Maragakis and Rothstein, 2006; Li et al., 2008), astrocytes also respond to signaling pathwa”
• Astrocytes: biology and pathology (2009, neutral): “4d) [225, 226].”
• Essential protective roles of reactive astrocytes in traumatic brain injury. (2006, background): “Moreover, different activities are likely to be context-dependent and regulated by a wide range of signalling cues (Sofroniew, 2005).”
• The bright side of the glial scar in CNS repair (2009, background): “Such an unbalanced response may be an outcome of an evolutionary process in which recovery from major CNS traumas was not a strong driving forc”
• Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “The concept of reactive astrogliosis and its molecular and cellular definition is still incomplete, and we are only starting to understand its multifaceted functions in disease pathogenesis and in the process of recovery from CNS injuries (17, 34, 52, 146, 210, 221) (FIGURE 1).”
• Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system. (2015, background): “On a morphological level, reactive astrogliosis ranges from mild to prominent, the latter being often accompanied by glial scarring [29].”
• Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury (2013, background): “…descriptive and mechanistic detail since that time (Ramon y Cajal, 1928; Silver and Miller, 2004), fundamental aspects of the cellular mechanisms, molecular regulation, and adaptive functions of astroglial contributions to scar formation remain poorly understood (Sofroniew, 2005, 2009).”