Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

By M. Todaro, M. P. Alea, A. B. Di Stefano, P. Cammareri, Louis Vermeulen, F. Iovino, C. Tripodo, A. Russo, G. Gulotta, J. Medema and 1 more. Cell Stem Cell, 2007

1,101 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/6acf6f4182423bf6568cc1d99509e76640a529c3

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Citations in the corpus

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity (2008, methodology): “Adherent plate differentiation was performed as described (5, 6) for 10 days.”
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer (2015, background): “CD44v6 is quite likely to be a suitable target for anticancer therapy because it is: (a) causally involved inmetastasis of a rat pancreatic carcinoma (187); (b) redundantly correlates with the human tumors mentioned above; and (c) correlates with oncogenic functions in colorectal cancer (CRC) both i”
Mechanisms of chemoresistance in cancer stem cells (2013, background): “When CD133 colon CSCs were treated with IL-4 neutralizing antibodies a decrease in BCL-XL as well as an increased sensitivity to oxaliplatin and 5-fluorouracil (5-FU) was observed [67].”
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. (2014, methodology): “CD44v6 Expression Demarcates a Highly Tumorigenic CR-CSC Population with Metastatic Potential We and others previously demonstrated that CR-CSCs are enriched in tumor spheres or freshly isolated CD133 cells (O’Brien et al., 2007; Ricci-Vitiani et al., 2007; Todaro et al., 2007).”
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. (2010, background): “2008), and enhanced survival of cancer stem cells (Todaro et al. 2007).”
Spherical Cancer Models in Tumor Biology (2015, background): “However, the latter spheres have also been termed “ spheroids ” [40], “ colonospheres ” [41,42], and more recently “ colospheres ” [43,44].”
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “An interleukin-4 (IL-4)-specific antibody reduced the viability of both CD133 − and CD133 + colon cancer cells and increased the efficacy of chemotherapy, suggesting that molecular pathways that contribute to bulk tumour growth can also be successfully targeted to sensitize tumour-initiating cells”