Parallel analysis of transcript and metabolic profiles: a new approach in systems biology

By Ewa Urbanczyk-Wochniak, Alexander Luedemann, Joachim Kopka, Joachim Selbig, U. Roessner-Tunali, Lothar Willmitzer, Alisdair R. Fernie. EMBO Reports, 2003

314 citations recorded by the source corpus.

Subfields: Materials Chemistry, Safety, Risk, Reliability and Quality

View Paper: https://www.semanticscholar.org/paper/c22485e39b7c9252efe3d89e59786e3e7ff51525

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Citations in the corpus

Statistical strategies for avoiding false discoveries in metabolomics and related experiments (2007, background): “…Cornish-Bowden and Ca´rdenas, 2000; Cascante et al., 2002), the variation in the metabolome is expected to be much greater (Raamsdonk et al., 2001; Urbanczyk-Wochniak et al., 2003; Kell, 2004), and thus we have the opportunity to achieve levels of statistical significance that the other omes are…”
Metabolomics by numbers: acquiring and understanding global metabolite data. (2004, background): “Thus, as the ‘downstream’ result of gene expression, changes in the metabolome are expected to be amplified relative to changes in the transcriptome and the proteome [ 12 ] .A s expected, metabolic fluxes (at least as exemplified by glycolysis in trypanosomes) are not regulated by gene expression al”
Correlative GC-TOF-MS-based metabolite profiling and LC-MS-based protein profiling reveal time-related systemic regulation of metabolite–protein networks and improve pattern recognition for multiple biomarker selection (2005, background): “Though not per se containing causality (Wagner, 1997), co-regulation of gene and protein expression analysis and the resulting metabolic phenotype correspond well to our understanding of the causal genotype–phenotype interplay (Cooper et al., 2002; Urbanczyk-Wochniak et al., 2003; Ihmels et al., 200”
Gut microorganisms, mammalian metabolism and personalized health care (2005, background): “There is widespread recognition of this complexity and the need to integrate the outputs of omics technologies into a systems approach to understand how multicellular biological systems operate in their environment”
Metabolomics for functional genomics, systems biology, and biotechnology. (2010, background): “org/ have been made in the case of the potato (206, 207) and tomato (5, 22) plants during their development and diurnal cycles.”