Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

By D. Wootten, J. Simms, L. Miller, Arthur Christopoulos, P. Sexton. 2013

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GPCRdb in 2021: integrating GPCR sequence, structure and function (2020, methodology): “The generic residue numbering uses a structural investigation to confirm or correct the receptor residue that corresponds to the reference position (designated the number 50) in each of TM1–7 using the sequence-based numbering scheme for the given GPCR class (A: BallesterosWeinstein (13), B1: Wootte”
A Structural Framework for GPCR Chemogenomics: What's In a Residue Number? (2018, methodology): “GPCR Classes Numbering schemes using a similar logic to the BW numbering have later been proposed by Wootten for class B [58], Pin for class C [59], and Wang for class F GPCRs [19].”
A combined activation mechanism for the glucagon receptor (2020, methodology): “In this work superscripts to the residue numbers refer to the Wootten numbering scheme (18); additionally, the superscript “P” is used for glucagon residues and “G” for Gαs.”
Structural insights into differences in G protein activation by family A and family B GPCRs (2020, methodology): “The functional relevance of these residues for activation of the glucagon receptor family have been previously shown by mutagenesis studies (20).”
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms (2021, background): “S10) that are recognized as important for class B1 receptor activation and biased agonism (27, 30) contribute to the packing of the receptor in the apo state.”