Evolutionary families of peptidase inhibitors.

By Neil D. Rawlings, Dominic P. Tolle, Alan J. Barrett. Biochemical Journal, 2004

600 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/c1c158af763ad915fa3bfab27a54bddf960dc788

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

In Molecular Biology

In Oncology

Citations in the corpus

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database (2017, methodology): “The hierarchical classification in MEROPS was established for peptidases in 1993 (1) and for peptidase inhibitors in 2004 (2).”
Cysteine cathepsins: From structure, function and regulation to new frontiers (2011, background): “systemof nomenclature on the basis of similarities at the amino acid sequence level and three-dimensional structures was introduced [209].”
Extreme climatic events: impacts of drought and high temperature on physiological processes in agronomically important plants (2014, background): “Proteolysis is performed by an impressive number of proteases—approximately 2% of the genes code for proteolytic enzymes (Rawlings et al., 2004).”
MEROPS: the peptidase database (2009, background): “The type example at the peptidase or inhibitor level is termed the ‘holotype’ (1,2).”
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors (2013, background): “A classification of the protein inhibitors of peptidases (5) was added in 2004 (4) and coverage of the mostly synthetic, small-molecule inhibitors (SMIs) was added in 2008 (6).”
Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors (2015, background): “The hierarchical classification, which was established for peptidases in 1993 (1) and for peptidase inhibitors in 2004 (2), involves the clustering of homologous sets of peptidase and protein inhibitor sequences into peptidase and inhibitor species, which are in turn clustered into families, which a”
Inducible direct plant defense against insect herbivores: A review (2008, background): “Since then, the roles of digestive enzyme inhibitors in plant defense have been extensively studied (reviewed by Ryan, 1990; Ussuf et al., 2001; Rawlings et al., 2005).”
Plant protease inhibitors: a defense strategy in plants (2007, background): “On the basis of sequence homologies of their inhibitor domains, PIs have been classified into 48 families (Rawlings et al., 2004b).”