TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation

By T. Ma, G. K. Iwamoto, N. Hoa, Vimesh Akotia, A. Pedram, M. Boivin, H. Said. 2004

801 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c17e7012695cb7c35bacf0a947f5c135f9bc711a

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Takuya Suzuki

Citations in the corpus

Regulation of intestinal epithelial permeability by tight junctions (2012, background): “TNF-a Increase Caco-2 ZO-1 ; [103] Increase Caco-2 MLCK :, pMLC : [104, 106] Increase HT29/B6 Claudin-2 : [107]”
NF-κB activation as a pathological mechanism of septic shock and inflammation (2006, positive): “NF- B activation mediates TNF- -induced increase in intestinal epithelial tight junction permeability (149).”
Cytokine regulation of tight junctions (2008, background): “A thorough investigation over several studies revealed that NF-κB acts to increase myosin light chain kinase (MLCK) transcription during TNF-α treatment [36-38].”
Tight junctions and the modulation of barrier function in disease (2008, background): “…that TNF induced an increase in Caco-2 TJ permeability mediated by activation of the pro-inXammatory transcription factor NF B. NF B action leads to a downregulation of speciWcally ZO-1 gene expression and a redistribution of ZO-1 protein away from the intercellular junctions (Ma et al. 2004).”
IL-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability (2015, positive): “TNF-a concentration is markedly increased in mouse models of IBD as well as CD patients, and TNF-a has been shown to disrupt tight junctions and increase epithelial barrier permeability in Caco-2 cells (Ma et al., 2004).”
Para-inflammation in the aging retina. (2009, background): “Endothelial tight junction integrity can be disrupted by various inflammatory cytokines (Ma et al., 2004; Stamatovic et al., 2003) and leukocyte–endothelial interaction (Edens and Parkos, 2000), in particular leukocyte transendothelial migration (Xu et al., 2005) can directly cause local transient…”