Tertiary lymphoid structures improve immunotherapy and survival in melanoma
By R. Cabrita, M. Lauss, Adriana Sanna, M. Donia, Mathilde Skaarup Larsen, Shamik Mitra, I. Johansson, Bengt Phung, K. Harbst, J. Vallon-Christersson and 15 more. Nature, 2020
1,961 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/c14800cb05b2a3e2d8bbf67cc4f4521cc8a829c6
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In Immunology
- Aviv Regev
- V. Kuchroo
- Arlene H. Sharpe
- A. Anderson
- Ton N. Schumacher
- D. Thommen
- Nir Hacohen
- David Mcilwain
In Oncology
Citations in the corpus
- Spatially organized multicellular immune hubs in human colorectal cancer (2021, background): “, 2016), contain germinal center B cells, and have been associated with high T cell activity, favorable prognosis, and effective response to immunotherapy (Cabrita et al., 2020; Coppola et al., 2011; Helmink et al., 2020; Petitprez et al., 2020; Sautès-Fridman et al., 2019).”
- Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front (2019, background): “The biological and clinical relevance of TLSs has been demonstrated not only in CRC but also in multiple other cancers (Binnewies et al., 2018; Cabrita et al., 2020; Di Caro et al., 2014; Dieu-Nosjean et al., 2016; Graham and Appelman, 1990; Helmink et al., 2020; Petitprez et al., 2020; Sautès-Fridm”
- Tumor-infiltrating lymphocytes in the immunotherapy era (2020, background): “Pretreatment TIL B cells by themselves are also associated with improved immunotherapy responses and better survival.(75,240,241) Helmink et al.”
- Tertiary lymphoid structures in cancer (2022, background): “Interestingly, TLS abundance correlated with programmed cell death ligand-1 (PD-L1) expression on immune cells (131, 132) but not on tumor cells (16).”