(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.
By H. Schroeter, C. Heiss, J. Balzer, P. Kleinbongard, C. Keen, N. Hollenberg, H. Sies, C. Kwik-Uribe, H. Schmitz, M. Kelm. Proceedings of the National Academy of Sciences of the United States of America, 2006
1,073 citations recorded by the source corpus.
Subfields: Biochemistry, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/c144c33caeea15313b1d9a27f33600f1cd7ff3a8
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Citations in the corpus
- Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action (2010, background): “Various human, animal and cell studies have suggested that polyphenols may exert beneficial effects on the vascular system via an induction of antioxidant defenses [103-105], by lowering blood pressure [98,106-111], by improving endothelial function [108,112-121], by inhibiting platelet”
- Endothelial dysfunction and vascular disease – a 30th anniversary update (2017, background): “…Alexopoulos et al. 2008, Jang et al. 2013), in grape juice (Anselm et al. 2007), in pomegranate juice (Nigris et al. 2006, 2007a,b) or in dark chocolate (Fisher et al. 2003, Engler et al. 2004, Grassi et al. 2005, Schroeter et al. 2006, Flammer et al. 2007, Taubert et al. 2007, Grassi et al. 2012).”
- Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. (2008, background): “The report by Schroeter et al (39) contains details of 2 distinct studies, labeled “A” and “B.”
- Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases (2013, positive): “With regard to endothelial function, a well-known surrogate marker for vascular health, flavan-3-ol-rich cocoa (176– 963 mg of flavan-3-ol monomers and oligomers), has been shown to acutely improve endothelium-dependent vasodilation assessed by flow-mediated dilation (FMD) via increasing plasma NO b”
- Dietary polyphenols: good, bad, or indifferent for your health? (2007, background): “This is not to say that all the observed cellular effects of flavonoids are artefacts; indeed, they may exert different effects on different cell types, those on vascular endothelial cells and other cells of the vascular system perhaps being especially important physiologically [43,82].”