Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia.

By K. Jin, X. Mao, D. Greenberg. Proceedings of the National Academy of Sciences of the United States of America, 2000

701 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c12cd9ecc2b536b840e779b668ed45af3a7f91da

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Adamis
2. Peter Carmeliet
3. Rakesh K. Jain
4. M. Sofroniew
5. N. Ferrara
6. J. Folkman
7. C. Iadecola

In Cellular and Molecular Neuroscience

1. W. Tyler
2. A. Adamis
3. Peter Carmeliet

In Molecular Biology

1. A. Adamis
2. Peter Carmeliet
3. Rakesh K. Jain
4. N. Ferrara
5. J. Joyce
6. M. Shibuya
7. J. Folkman
8. C. Iadecola

Citations in the corpus

• VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model (2004, background): “Recent reports have indicated that reduced levels of vascular endothelial growth factor (VEGF), which is essential in angiogenesis and has also been implicated in neuroprotectio”
• Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. (2007, positive): “In addition, investigators have demonstrated that VEGF-A also has direct protective effects on cultured neuronal cells in situations such as N-methyl-D-aspartic acid-induced toxicity(33) or ischemic insult.(1) The neuroprotective function of VEGF-A in the retina has not been characterized, despite t”
• Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound (2008, background): “Moreover, VEGF [49,50], TGF-b [51,52], and bFGF [46] are neuroprotective against hypoxic-ischemic injury and neurodegeneration.”
• VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. (2003, neutral): “In previous studies, we found that VEGF reduced neuronal death from hypoxia in vitro and that this involved activation of the VEGFR2/ Flk1 receptor and PI3K and decreased activation of caspase-3 (19, 20).”
• VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown (2009, background): “Interestingly, in addition to its well recognized role in angiogenesis, VEGF-A has also been shown in recent work to be directly neuroprotective in rodent models of neurodegeneration (28, 29); thus, its effects within the CNS are more complex than previously appreciated.”