DNA methylation landscapes: provocative insights from epigenomics

By Miho M. Suzuki, A. Bird. Nature reviews genetics, 2008

3,025 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/b333db3f40802315f0535711b679710991ce8327

How researchers see this paper

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In Molecular Biology

1. Hao Wu
2. Yi Zhang
3. Manel Esteller
4. Hongjun Song
5. Guo-li Ming
6. Aviv Regev
7. Bing Ren
8. W. Grady

In Plant Science

1. Yi Zhang
2. Hao Wu
3. Alexander Meissner
4. Julie A. Law
5. Steven E. Jacobsen
6. Ryan Lister
7. Andrew D. Smith
8. P. Molloy

Citations in the corpus

• Linking DNA methylation and histone modification: patterns and paradigms (2009, background): “Regions that have a methylated profile are reassembled in a closed conformation, whereas unmethylated DNA tends to get repackaged in a more open configuratio”
• Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells (2014, methodology): “For DNA methylation, we calculated the mCG density within the region spanning from 1 kb upstream of TSS to TSS; we did not consider sequences downstream from TSS to avoid tracking increased methylation in gene bodies of expressed genes (Suzuki and Bird 2008).”
• Epigenetics and Colorectal Cancer (2011, background): “Since that time, research has revealed an 'epigenetic landscape' consisting of a complex array of epigenetic regulatory mechanisms that control gene expression in both normal tissue and cancerous tissue”
• methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles (2012, background): “DNA methylation is a critical epigenetic modification that guides development, cellular differentiation and the manifestation of some cancers [1,2].”
• Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood (2012, background): “Background DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression [1], but the tissue-specific nature of DNA methylation has not been fully characterized at a genomic level.”
• Cancer epigenetics reaches mainstream oncology (2011, background): “Although in the latter case most of the CpGs are methylated to prevent chromosome instability, the majority of CpG islands remain unmodified during development and in differentiated tissue”
• De novo identification of differentially methylated regions in the human genome (2015, background): “DMRs may occur throughout the genome, but have been identified particularly around the promoter regions of genes, within the body of genes, and at intergenic regulatory regions [9-13].”