Structural Basis of Collagen Recognition by Integrin α2β1

By J. Emsley, C. Knight, R. Farndale, Michael J. Barnes, R. Liddington. 2000

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Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. (2002, background): “The MIDAS motif is perfectly conserved in all integrin subunit VWA domains and interaction with ligand involves mutual coordination of metal ion (Emsley et al., 2000).”
Integrin structure, activation, and interactions. (2011, background): “A crystal structure of a complex between the a2 I-domain and a triple-helical collagenous peptide has revealed the structural basis of the interaction, with a critical glutamate within a collagenous GFOGER motif providing the key cation-coordinating residue (Emsley et al. 2000).”
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site (2001, background): “Statins do not block the β 2 integrin Mac-1 Recent studies provide evidence that sites similar to the L-site are also present in other integrins that have an I-domai”
INTEGRIN LIGANDS (2006, background): “A crystal structure of a complex between the 2 A-domain and a triple-helical collagenous peptide has revealed the structural basis of the interaction, a critical glutamate within a collagenous GFOGER motif providing the key cation-coordinating residue (Emsley et al., 2000).”