Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.

By C. A. Whittaker, R. Hynes. Molecular Biology of the Cell, 2002

769 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/0296e8dac94e51a73661adccb807841791bf4481

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Eugene V. Koonin
2. Yuri I. Wolf
3. Kira S. Makarova
4. W. D. de Vos

Citations in the corpus

• The Calcium Channel α2δ-2 Subunit Partitions with CaV2.1 into Lipid Rafts in Cerebellum: Implications for Localization and Function (2006, background): “This VWA domain is present in all 2 subunits and has a perfect MIDAS motif in 2 -1 and 2 -2 (Whittaker and Hynes, 2002).”
• The Gabapentin Receptor α2δ-1 is the Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis (2009, positive): “It is known for integrins that conformational changes in VWF-A domains can be constrained by interactions made by regions flanking this domain (Bork and Rohde, 1991; Whittaker and Hynes, 2002).”
• A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes (2004, background): “J All archaea, no bacteria (COG1798) 1 1 0261 RNA polymerase III, largest subunit RNAPIII holoenzyme K All (COG0086) 0 X 0262 RNA polymerase I, largest subunit RNAPI holoenzyme K All (COG0086) 0 X 0215 RNA polymerase III, second largest subunit RNAPIII holoenzyme K All (COG0085) 0 X 0216 RNA polymer”
• Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein (2009, background): “Despite interacting primarily with human extracellular matrix proteins (34), a region of the vWFA domain (residue 201–299) demonstrates weak homology with a fucose-binding lectin domain, suggesting that the vWFA-like domain in SpaC may bind in a lectin-type manner, a distinct plausibility considerin”
• Functional Analysis of the RING-Type Ubiquitin Ligase Family of Arabidopsis1[w] (2005, background): “The PPR domain is present mainly in plant proteins (Small and Peeters, 2000), while the vWA, KISc, and Znf_ZZ domains are widely dispersed among different species (Ponting et al., 1996; Block, 1998; Whittaker and Hynes, 2002).”
• The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential (2015, background): “A further gene was also identified by homology (Whittaker and Hynes, 2002).”