Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

By G. Weitz-Schmidt, K. Welzenbach, V. Brinkmann, T. Kamata, J. Kallen, C. Bruns, S. Cottens, Y. Takada, U. Hommel. Nature Medicine, 2001

1,093 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. (2008, background): “Inhibition of β2-integrin function-associated antigen-1 can decrease lymphocyte adhesion to ICAM-1 and impair T-cell co-stimulation [98].”
LXR signaling couples sterol metabolism to proliferation in the acquired immune response (2008, background): “Indeed, much of the immunomodulatory effects of statins have been attributed to the biology of these products (Kwak et al., 2000; Weitz-Schmidt et al., 2001).”
Rolling Adhesion through an Extended Conformation of Integrin αLβ2 and Relation to α I and β I-like Domain Interaction (2004, background): “…locked in the open conformation (Kallen et al., 1999; Last-Barney et al.,conformation with a disulfide-bond mediate firm adhe2001; Liu et al., 2001; Weitz-Schmidt et al., 2001), andsion (Salas et al., 2002), as do L 2 integrins activated also inhibit activation epitope exposure in L 2 (Shi-by Mn2…”
Pleiotropic Effects of Statins on the Cardiovascular System (2017, background): “could bind to an allosteric site within the β2 integrin leukocyte function–associated antigen-1.(41) Leukocyte function–associated antigen-1 is involved in leukocyte trafficking and T-cell activation and binds intercellular adhesion molecule-1.”