Cancer active targeting by nanoparticles: a comprehensive review of literature
By R. Bazak, Mohamad T Houri, S. E. Achy, S. Kamel, T. Refaat. Journal of Cancer Research and Clinical Oncology, 2014
641 citations recorded by the source corpus.
PurposeCancer is one of the leading causes of death, and thus, the scientific community has but great efforts to improve cancer management. Among the major challenges in cancer management is development of agents that can be used for early diagnosis and effective therapy. Conventional cancer management frequently lacks accurate tools for detection of early tumors and has an associated risk of serious side effects of chemotherapeutics. The need to optimize therapeutic ratio as the difference with which a treatment affects cancer cells versus healthy tissues lead to idea that it is needful to have a treatment that could act a the “magic bullet”—recognize cancer cells only. Nanoparticle platforms offer a variety of potentially efficient solutions for development of targeted agents that can be exploited for cancer diagnosis and treatment. There are two ways by which targeting of nanoparticles can be achieved, namely passive and active targeting. Passive targeting allows for the efficient localization of nanoparticles within the tumor microenvironment. Active targeting facilitates the active uptake of nanoparticles by the tumor cells themselves.MethodsRelevant English electronic databases and scientifically published original articles and reviews were systematically searched for the purpose of this review.ResultsIn this report, we present a comprehensive review of literatures focusing on the active targeting of nanoparticles to cancer cells, including antibody and antibody fragment-based targeting, antigen-based targeting, aptamer-based targeting, as well as ligand-based targeting.ConclusionTo date, the optimum targeting strategy has not yet been announced, each has its own advantages and disadvantages even though a number of them have found their way for clinical application. Perhaps, a combination of strategies can be employed to improve the precision of drug delivery, paving the way for a more effective personalized therapy.
Subfields: Mechanical Engineering, Ocean Engineering, Statistics and Probability
View Paper: https://www.semanticscholar.org/paper/1814f72fe71aab9ef2a62c60efe17ba78133e4d5
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Citations in the corpus
- Innovative approaches for cancer treatment: current perspectives and new challenges (2019, background): “Nanoparticles, for example, can be functionalized with ligands that univocally bind particular cells or subcellular sites [6].”
- Engineering the Delivery System for CRISPR-based Genome Editing (2018, background): “These can range from passive size-based approaches which leverage native uptake and clearance mechanisms [60] or the tumor-specific EPR effects [61], to the inclusion of a wide range of active targeting ligands to direct drug delivery to a particular organ [62, 63].”