MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.

By F. Meng, R. Henson, H. Wehbe-Janek, K. Ghoshal, S. Jacob, T. Patel. Gastroenterology, 2007

2,826 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c0b3f5871796982323a30268485d6e39f5b517ed

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Citations in the corpus

microRNA as Biomarkers and Diagnostics (2016, background): “Microrna-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular carcinoma.”
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer (2011, background): “A large and growing body of literature shows the involvement of miRNAs in hepatocarcinogenesis (Meng et al., 2007; Coulouarn et al., 2009; Gramantieri et al., 2009; Ji et al., 2009; Su et al., 2009; Wang et al., 2009; Braconi et al., 2010; Pineau et al., 2010).”
Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges (2010, neutral): “Additional studies showed that miR-21 exerts its anti-apoptotic effects by targeting the tumour suppressors phosphatase and tensin homologue ( PTEN ) and programmed cell death 4 (Ref”
miR-221 overexpression contributes to liver tumorigenesis (2009, background): “Furthermore, another up-regulated member of the progression signaturedefined in thepresent report,miR-21, is known to target the PTEN tumor suppressor (28).”
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin (2008, background): “1A and B ; Supplementary Table S1) in MCF-7/DOX cells was associated with the decreased level of their targets ERa, RB1, and PTEN proteins (32–36), respectively, resulting in estrogen insensitivity and increased survival of MCF-7/ DOX resistant cells.”
MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. (2009, positive): “Recently, PTEN has been validated as a target gene for miR-21.(17) PTEN is a dual protein–lipid phosphatase which dephosphorylates the secondary messenger produced by PI3K and interrupts the downstream activation of Akt.”
MicroRNAs in development and disease. (2011, background): “Other miRNAs with oncogenic functions (oncomirs) in HCC include the following: miR21, which suppresses PTEN and is associated with an increase in phospho-AKT, phospho-focal adhesion kinase (pFAK), and metalloproteinase 2 (MMP2) (417); miR-221, which inhibits the cell cycle inhibitors p27 and p57 (18”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “Additional studies showed that miR-21 anti-apoptotic effects occurs by targeting the tumour suppressors phosphatase and tensin homologue (PTEN) and programmed cell death 4 (PDCD4) (Frankel et al, 2008; Meng et al, 2007).”
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification (2020, background): “Interferon regulatory factor 2 (IRF2) and chromobox 7 (CBX7) are direct targets of miR-18a and BCL2-Like 10 (BCL2L10) is a downstream mediator of miR-18a (Wang et al., 2018; Yongyu et al., 2018). miR-21 is involved in tumor proliferation, migration and invasion and directly targets phosphatase and t”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Further work identified PTEN and tropomyosin 1 as direct targets of miR-21 in cancer cell lines (Zhu et al., 2007; Meng et al., 2007a).”
Modulation of K-ras-dependent lung tumorigenesis by microRNA-21 (2010, neutral): “, 2007), hepatocellular (Meng et al., 2007), and cervical carcinoma (Lui et al.”