A new approach to decoding life: systems biology.

By Trey Ideker, Timothy Galitski, Leroy Hood. Annual review of genomics and human genetics (Print), 2001

1,809 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c051123535d424339306e523b2ed702901819a84

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Citations in the corpus

Systems biology in drug discovery (2004, background): “1 ), such efforts are currently limited to simple organisms or to specific minimal pathways (and generally in very specific cell and environmental contexts) in higher organism”
Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. (2005, background): “We are undergoing a more modern synthesis that merges multiple disciplines into what has been referred to as systems biology.((74))”
Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment (2019, background): “…systems by systematically perturbing them; monitoring the gene, protein, and informational pathway responses; integrating these data; and, ultimately, formulating mathematical models to describe the structure of the system and its response to individual perturbations (Ideker et al., 2001).”
A white-box machine learning approach for revealing antibiotic mechanisms of action (2019, positive): “Network modeling has long provided a foundation for systems biology (Ideker et al., 2001), and researchers are now beginning to integrate machine learning with retrospective network modeling for improving the fidelity of genotype-to-phenotype predictions (Ma et al.”
A review of imaging techniques for systems biology (2008, background): “Systems biology [ 1-8 ] attempts to model the dynamics and structure of complete biological systems.”
Parallel analysis of transcript and metabolic profiles: a new approach in systems biology (2003, result): “…as would be expected from previous experimental work aimed at comparing transcript and protein levels (Futcher et al. , 1999; Gygi et al. , 1999; Ideker et al. , 2001) and mathematical studies (ter Kuile & Westerhoff, 2001), we believe they allow the generation of clear, testable hypotheses.”
Review of Aroma Formation through Metabolic Pathways of Saccharomyces cerevisiae in Beverage Fermentations (2016, background): “The data from multiple -omics approaches may be integrated, graphically viewed, and modeled to predict how a particular system functions under a given set of conditions (Ideker et al. 2001).”
Chapter 1. General introduction (2015, neutral): “…books Built by scientists, for scientists 12.2% 117,000 130M TOP 1%154 4,400 Chapter 1 General Introduction: Advances in Hepatic Surgery J.H.M.B. Stoot, R.J.S. Coelen, J.L.A. van Vugt and C.H.C. Dejong Additional information is available at the end of the chapter http://dx.doi.org/10.5772/54710”
A Linear Representation of Dynamics of Boolean Networks (2010, background): “We refer to [20], [24] for a general introduction to systems biology.”