A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

By Yingli Sun, Xiaofeng Jiang, Shujuan Chen, N. Fernandes, B. Price. Proceedings of the National Academy of Sciences of the United States of America, 2005

779 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/bf5d94358d6390adbae9e23fe07872da35e9cd48

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Xiang-Jiao Yang
2. E. Seto
3. L. Zou
4. Graham C. Walker
5. Nimrat Chatterjee
6. Alexandre Maréchal

In Oncology

1. E. Seto
2. L. Zou
3. Graham C. Walker
4. Nimrat Chatterjee
5. Alexandre Maréchal
6. Xiang-Jiao Yang

Citations in the corpus

• Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006, background): “It should be noted that interpretations drawn from experiments involving TIP60 and hMOF shRNA regarding p53 signaling should consider that both TIP60 and hMOF also participate in the DNA damage signaling pathway at points that lie well upstream of p53 activation and K120 acetylation (Gupta et al., 2”
• DNA damage sensing by the ATM and ATR kinases. (2013, background): “The FATC domain of ATM interacts with the acetyltransferase Tip60 and is required for efficient ATM activation through an unknown mechanism (Sun et al. 2005).”
• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “TIP60 acetylates and activates ATM kinase in response to DNA damage (Sun et al., 2005).”
• Mechanisms of DNA damage, repair and mutagenesis (2017, positive): “The MRN (MRE11-RAD50-NBS1) complex initiates HR at a DSB, where it recognizes and binds the DSB and then recruits ATM and TIP60 to the DNA [Sun et al., 2005; Stracker and Petrini, 2011].”