A putative flip–flop switch for control of REM sleep

By Jun Lu, D. Sherman, M. Devor, Clifford B. Saper. Nature, 2006

1,173 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/bf5986cc2ba19fcabcef59ca380dd4df311c5253

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In Cellular and Molecular Neuroscience

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In Experimental and Cognitive Psychology

Citations in the corpus

REM sleep and dreaming: towards a theory of protoconsciousness (2009, background): “Recent work has revealed additional mechanistic details regarding neuronal contro”
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. (2007, background): “Lesions of MCRF neurons, sparing fibres of passage, failed to alter EMG atonia in REM sleep (Lu et al., 2006); thus, prior lesioning studies implicating the MCRF in REM sleep atonia may have inadvertently disrupted the descending SLD projections, which accounted for the findings.”
Histamine in the nervous system. (2008, background): “During cataplexy, a cardinal symptom of narcolepsy, muscle tone is lost but not consciousness (433, 680).”
Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part I: Principles of Functional Organisation (2008, background): “An area in the subcoeruleus surrounding the LC has been identified as containing “REM-on” neurones that receive an inhibitory GABAergic projection from “REM-off” neurones in the ventrolateral PAG [212, 327].”
The cortisol awakening response: more than a measure of HPA axis function. (2010, background): “Such flip-flop switching of brain areas arises from activation of mutually inhibitory neuronal pathways orchestrated by a control system in the pontine brainstem (Lu et al., 2006).”
Neural Circuitry of Wakefulness and Sleep (2017, positive): “The vlPAG/LPT sendsGABAergic projections to the SLD, and lesions or pharmacological inactivation of the vlPAG/LPT region increase REM sleep (Lu et al., 2006b; Sapin et al., 2009).”
Multimodal fast optical interrogation of neural circuitry (2007, background): “Author Information The GenBank accession number is EF474018 for the ‘mammalianized’ NpHR sequence and EF474017 for the ‘mammalianized’ ChR2(1-315) sequence.”
Pathophysiology of sleep apnea. (2010, background): “This powerful effect of state has been adequately documented in tracheostomized animal models (374) and recently has been demonstrated in OSA patients in whom the potentially confounding, compensatory responses to sleep-induced changes in upper airway resistance, negative pressure, PaCO2, and respir”
How (and why) the immune system makes us sleep (2009, neutral): “Serotonergic neurons in the raphe nuclei, like noradrenergic neurons in the locus coeruleus, are considered to be part of the systems that gate REM sleep by inhibiting the neurons that promote i”
Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “Furthermore, the vlPAG participates in mechanisms of arousal, through the activation of dopaminergic neurons during wakefulness and inactivation of these neurons during sleep (549), and vlPAG is also involved in the switch between non-REM and REM sleep (286, 550).”