Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

By A. Budanov, A. Sablina, E. Feinstein, Eugene V. Koonin, P. Chumakov. Science, 2004

754 citations recorded by the source corpus.

Subfields: Biochemistry, Biotechnology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bf2ce05a249ef4e1987d66bf51dd00d80d275c3b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. A. Budanov
2. Beth Levine
3. Guido Kroemer
4. Alec C. Kimmelman
5. D. Rubinsztein
6. F. Pietrocola
7. J. Keaney

In Biotechnology

1. Karen H. Vousden
2. M. Karin
3. A. Budanov
4. Guido Kroemer
5. Arnold J. Levine
6. Alec C. Kimmelman
7. T. Mak
8. Navdeep S. Chandel

In Molecular Biology

1. Guido Kroemer
2. Beth Levine
3. L. Galluzzi
4. Karen H. Vousden
5. M. Karin
6. A. Budanov
7. Eric H. Baehrecke
8. Arnold J. Levine

Citations in the corpus

• Role of oxidative modifications in atherosclerosis. (2004, background): “Alternatively, the sulfenic acid may become oxidized further to sulfinic acid so that it is no longer reduced by thioredoxin (1082), but instead by a recently discovered, sestrin-dependent reduction pathway (103, 1062).”
• The antioxidant function of the p53 tumor suppressor (2005, background): “In addition, the function of two p53-regulated sestrins, PA26 and Hi95 (encoded by SESN1 and SESN2 , respectively), is essential for regeneration of overoxidized peroxiredoxin”
• Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function (2010, background): “Sestrins are a family of proteins required for regeneration of peroxiredoxins, the major reductants of endogenously produced peroxides in cells (9).”
• The CASTOR proteins are arginine sensors for the mTORC1 pathway (2016, positive): “(D) A model depicting how the cytosolic and lysosomal amino acid inputs impinge on CASTORs, Sestrins, and SLC38A9 to regulate mTORC1 activity.”
• Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders (2010, neutral): “The products of these genes can mediate this reactio”
• TIGAR, a p53-inducible regulator of glycolysis and apoptosis. (2006, background): “The sestrins have been identified as a family of p53-inducible proteins that provide an antioxidant defense to protect cells from hydrogen peroxide (H2O2) induced damage (Budanov et al., 2004).”
• p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. (2008, positive): “However, a redox-inactive Sesn2(C125S) mutant (Budanov et al., 2004) was as effective as WT Sesn2 in inhibition of p70S6K and S6 phosphorylation (Figure 1C).”
• Regulation of cancer cell metabolism (2011, background): “, but it also has an important role in reducing oxidative stress as a defence mechanis”