Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex.

By M. Hamann, D. Rossi, David Attwell. 2002

368 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Neurology

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “, 1996) ensures a high spike threshold (Hamann et al., 2002) that typically requires activation of three of the four mossy fibre inputs (D’Angelo et al.”
GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum (2005, background): “Synaptic basis of the tremor GAT1 inhibition causes elevated extracellular [GABA] and therefore generates an increased tonic GABAA-mediated conductance, perhaps primarily by acting at areas that typically express high-affinity, nondesensitizing GABAA receptors (Brickley et al., 1996; Wall and Usowic”
NMDA receptors with incomplete Mg2+ block enable low-frequency transmission through the cerebellar cortex (2012, background): “Tri-heteromeric GluN2A/C receptors, in contrast, are only inhibited by 20% in 1.2 M free Zn 2 (Hatton and Paoletti, 2005).”
Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo‐ocular learning (2012, neutral): “At this concentration, bumetanide has no effect on GABA A Rs of GCs (Korpi et al , 1995; Hamann et al , 2002).”
Purkinje cells directly inhibit granule cells in specialized regions of the cerebellar cortex (2016, positive): “Since neither MLIs nor PCs make direct connections to GoCs to provide feedback control of the input layer (Hull and Regehr, 2012; Witter et al., 2016), it is thought that cerebellar computations are carried out sequentially: inputs are first processed in the GrC layer and then interpreted by the PCs”
Neurosteroids: endogenous regulators of the GABAA receptor (2005, background): “For example, the tonic conductance in rat CGCs, in contrast to that in mouse CGCs, is relatively insensitive to 3α,5α-THDO”
Contributions of the GABAA Receptor α6 Subunit to Phasic and Tonic Inhibition Revealed by a Naturally Occurring Polymorphism in the α6 Gene (2006, background): “The abundance of this allele in rats (Hanchar et al., 2005) could explain variability in previous reports regarding the sensitivity of tonic inhibition in CGCs to benzodiazepines (Leao et al., 2000; Hamann et al., 2002; Wall, 2005).”
Granule Cell Ascending Axon Excitatory Synapses onto Golgi Cells Implement a Potent Feedback Circuit in the Cerebellar Granular Layer (2013, background): “Golgi cells (GoCs) constitute the only source of inhibition to cerebellar granular cells (GrCs) (Eccles et al., 1967; Hamann et al., 2002; Crowley et al., 2009), and their acute ablation causes severe ataxia (Watanabe et al., 1998).”
Integration of quanta in cerebellar granule cells during sensory processing (2004, background): “This indicates that a tonic GABA A receptor-mediated conductanc”
Shunting inhibition modulates neuronal gain during synaptic excitation. (2003, background): “We establish that tonic shunting inhibition reduces the gain of the f-F relation- steps in these (Brickley et al., 1996; Hamann et al., 2002) and other cells (Berman et al., 1992; Connors et al.,ship and elucidate the underlying biophysical mecha- nisms.”
Tonically active GABA A receptors: modulating gain and maintaining the tone. (2004, background): “Low concentrations of the antagonist SR95531 (gabazine) completely abolish IPSCs while having little or no effect on tonic GABAA-receptormediated signalling in hippocampal neurons [10,11,13,20], and furosemide (frusemide), a selective blocker of a6containing receptors, selectively blocks the tonic c”
Properties of Somatosensory Synaptic Integration in Cerebellar Granule Cells In Vivo (2006, background): “…vitro studies, in which it has been suggested that the role of Golgi cell inhibition in granule cells is to set the excitability level on a longer time scale using a predominantly tonic form of inhibition (Brickley et al., 1996; Wall and Usowicz, 1997; Rossi and Hamann, 1998; Hamann et al., 2002).”