The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies.

By P. Farci, A. Shimoda, A. Coiana, G. Diaz, G. Peddis, J. Melpolder, A. Strazzera, D. Chien, S. Munoz, A. Balestrieri and 2 more. Science, 2000

957 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/bef51ae41169f5518f1e9695052f8257ebc867e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Eileen M. Foy
2. Brett D. Lindenbach Heinz-J
3. M. Gale
4. Peter Simmonds
5. Charles M. Rice
6. Andrew Rambaut
7. B. Rehermann
8. M. Nascimbeni

In Hepatology

1. Eileen M. Foy
2. Brett D. Lindenbach Heinz-J
3. M. Gale
4. M. Nascimbeni
5. B. Rehermann
6. Peter Simmonds
7. Charles M. Rice

Citations in the corpus

• Genetic diversity and evolution of hepatitis C virus--15 years on. (2004, background): “This variability may arise through specific selection (Darwinian) mechanisms operating on the virus that are associated with immune escape; for example, the HVR in E2 may be a target for neutralizing antibody and persistence may therefore require continuous virus sequence change to evade B-cell resp”
• Flaviviridae :T he Viruses and Their Replication (2007, background): “HVR1 exhibits a high level of sequence variability even within a single patient, largely driven by immunogic selection (188,463,497,754).”
• Evasion of intracellular host defence by hepatitis C virus (2005, background): “Indeed, sequencing studies have shown that the resolution of acute HCV infection is associated with an overall reduction in viral quasispecies complexity within the E1 and E2 coding regions of HCV, whereas progression to chronic infection and resistance to IFN therapy is associated with increased vi”
• Adaptive immune responses in acute and chronic hepatitis C virus infection (2005, background): “, and infection outcome in humans was predicted by sequence changes in the hypervariable-1 region of the E2 envelope glycoprotein, a major target of the antibody response, that occurred simultaneously with antibody seroconversio”
• Evolutionary analysis of the dynamics of viral infectious disease (2009, background): “equivalent studies of HCV infection have found that viral adaptation predicts the outcome of acute infection 78, 79 and that HCV diversity correlates with levels of liver damage 80 .”
• Immunology of hepatitis B virus and hepatitis C virus infection (2005, result): “, which is consistent with the emergence of HCV escape mutant”