Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms.

By Maria Ester Bernardo, N. Zaffaroni, F. Novara, A. Cometa, M. Avanzini, A. Moretta, D. Montagna, R. Maccario, R. Villa, M. Daidone and 2 more. Cancer Research, 2007

707 citations recorded by the source corpus.

Subfields: Genetics, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/bea7e42b25639747933efe4123daabb6b41e1dfd

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In Genetics

1. M. Kwa
2. Z. Bhat
3. C. Herberts
4. H. Fayaz
5. H. Hermsen

In Surgery

1. Z. Bhat
2. H. Fayaz

Citations in the corpus

• Prospectus of cultured meat—advancing meat alternatives (2011, background): “It has been observed that adipose tissue-derived adult stem cells immortalize at high frequency and undergo spontaneous transformation in long-term (4–5 months) culturing (Rubio et al. 2005), while evidence of adult stem cells remaining untransformed have also been reported (Bernardo et al. 2007).”
• Risk factors in the development of stem cell therapy (2011, background): “No supporting evidence for transformation of human MSC has been found independently by several authors, even after extensive genetic characterisation [ 59-61 ].”
• Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. (2009, background): “Studies indicating no spontaneous transformation in long-term hMSC cultures have been reported (9, 10).”
• Mesenchymal stromal cells: sensors and switchers of inflammation. (2013, neutral): “In contrast with these findings , (malignant) transformation of human MSCs has not been directly demonstrated and attempts to induce a malignant phenotype by long-term ex vivo expansion have been unsuccessful (Bernardo et al., 2007).”
• Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, neutral): “Human MSCs have largely been shown to be free of such transformative events [26–28].”