The role of glutathione in cancer

By G. Balendiran, R. Dabur, D. Fraser. Cell Biochemistry and Function, 2004

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Glutathione dysregulation and the etiology and progression of human diseases (2009, methodology): “On the other hand, elevated GSH levels are observed in various types of cancerous cells and solid tumors, and this tends to make these cells and tissues more resistant to chemotherapy (Calvert et al., 1998; Balendiran et al., 2004; Estrela et al., 2006).”
Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “The significantly upregulated production of antioxidants by cancer cells also prevents cells from undergoing autophagy or apoptosis (26, 53).”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “Another mechanism that might be involved in chemoresistance is increased levels of GSH in cancer cells [92].”
Role of Glutathione in Cancer Progression and Chemoresistance (2013, background): “Moreover, overexpression of specific GSTs can also affect chemoresistance, whereas polymorphisms that decrease GST activity are associated with a high risk of developing cancer [72].”