Cell Type–Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1

By B. Kelly, S. Hackett, K. Hirota, Y. Oshima, Z. Cai, S. Berg-Dixon, Ashley Rowan, Zhijiang Yan, P. Campochiaro, G. Semenza. Circulation Research, 2003

604 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/be4be89fa1a19eae24b2d58179825faad37fc2b3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. C. V. Dang
3. Ping Gao
4. Jung-whan Kim
5. N. Prabhakar
6. J. Tatum
7. S. Påhlman
8. C. Wigerup

In Genetics

1. G. Semenza
2. C. V. Dang
3. N. Prabhakar
4. J. Tatum
5. Navdeep S. Chandel

In Molecular Biology

1. G. Semenza
2. C. V. Dang
3. Ping Gao
4. Jung-whan Kim
5. S. Påhlman
6. C. Wigerup
7. D. Bexell
8. J. Tatum

Citations in the corpus

• Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. (2005, background): “…gain-of-function studies using a constitutively active form of HIF-1 have demonstrated that apart from VEGF, HIF-1 controls the expression of many other angiogenic factors, such as placenta-like growth factor, platelet-derived growth factor , and angiopoietin (Ang)-1 and -2 (Kelly et al., 2003).”
• ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “Expression of the ANGPT1 and ANGPT2 genes can be activated or repressed by hypoxia, depending on the cell type, and in each case the response is HIF-1 dependent (153).”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “Other hypoxia-induced pro-angiogenic factors include platelet-derived growth factor-β (PDGF-β) (Kelly et al., 2003), angiopoietin-2 (ANGPT2) (Kelly et al., 2003), and stromal-derived factor 1α (SDF-1α) (Ceradini et al., 2004), all of which promote neoangiogenesis.”
• Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy (2006, background): “Angiopoietin 1, placental growth factor, and platelet-derived growth factor B expression are also affected by HIF-1a (Arbeit 2002, Kelly et al. 2003, Vengellur et al. 2003).”
• Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1 (2007, methodology): “To determine whether HIF-1 could synergize with c-Myc in P493-6 tumorigenesis, we introduced a constitutively active form of HIF-1 (CA5-HIF-1) with the oxygen-dependent domain deleted and several prolines mutated as previously described ( 35 ) into P493-6 cells and found that tumor growth is signifi”
• HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. (2007, positive): “These results are consistent with previous studies demonstrating that the battery of HIF-1 target genes expressed in response to hypoxia differ from one cell type to another (Kelly et al., 2003).”