Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer.

By S. Mahmoud, E. Paish, D. Powe, R. Macmillan, M. Grainge, Andrew H. S. Lee, Ian O. Ellis, A. Green. Journal of Clinical Oncology, 2011

1,221 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/be27b9b75f78e7226cf9d743289c49636c14a022

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Citations in the corpus

Stroma Cells in Tumor Microenvironment and Breast Cancer (2012, positive): “Interestingly, recent findings also suggest that infiltrating number of CD8 T lymphocytes positively correlate with patient survival [122] and that high CD8 and low FOXP3 cells infiltrating after neoadjuvant chemotherapy were significantly related to improved recurrence-free survival and overall sur”
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial. (2014, methodology): “In this study, TILs were evaluated using full-face H&E-stained sections, which does make it practical for routine use, in contrast to the use of tissue microarrays [37].”
Defining T cell states associated with response to checkpoint immunotherapy in melanoma (2018, positive): “A central finding from our study is that the presence of TCF7 protein in CD8 T cells can predict clinical response to checkpoint therapy, suggesting that the state of T cells, in addition to the number of T cells and their spatial distribution (Galon et al., 2006; Mahmoud et al., 2011; Sharma et al.”
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. (2013, neutral): “Traditionally, CD8 + cytotoxic T cells have been considered as the key component of effective antitumor immunity, and breast tumors with higher levels of infiltrating CD8 + T cells have been associated with better patient survival (15, 16).”
Stacked Sparse Autoencoder (SSAE) for Nuclei Detection on Breast Cancer Histopathology Images (2015, positive): “Additionally, the quantitative assessment of lymphocytes in breast tissue has been recently recognized as a strong prognostic predictor of favourable outcome [3].”
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. (2015, background): “In BC, extensive tumor infiltration by cytotoxic CD8+ T cells was strongly associated with patient survival [10, 11] and response to therapy [12].”
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors (2014, background): “Similar positive prognostic import has been observed in breast cancer (Mahmoud et al., 2011) and in ovarian cancer (Hwang et al.”
The updated landscape of tumor microenvironment and drug repurposing (2020, background): “Tumor-infiltrating cytotoxic T cells are correlated with better prognosis in breast cancer.(220) Meanwhile, increased TIL infiltration and PD-L1 level are also seen in patients with TNBC.”