IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

By S. Dubois, J. Mariner, T. Waldmann, Y. Tagaya. 2002

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Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “For this to occur, soluble IL-15 binds to IL-15Rα on the surface presenting cells which trans-present this complex to apposing NK cells expressing IL2-Rβ/γc heterodimers (79).”
Interleukin 12: still a promising candidate for tumor immunotherapy? (2014, background): “Thus, IL-15 seems to function under normal circumstances as a cell-bound cytokine and is trans-presented to responding cells together with co-stimulatory signals ([46] and reviewed in [55]), although the dominance of trans-presentation of IL-15 to CD8 T cells has recently been called into question [”
Dendritic cells prime natural killer cells by trans-presenting interleukin 15. (2007, background): “Previous work showed that IL-15 is trans-presented on the surface of IL-15-producing cells in complex with IL-15Ra, which created an IL-15 gradient and confining the action of IL-15 (Dubois et al., 2002; Koka et al., 2004).”
New insights into the regulation of T cells by γc family cytokines (2009, neutral): “; in this system, IL-15 that is bound to IL-15Rα is presented to cells expressing the other IL-15R subunits, IL-2Rβ and γ c”