Robustness, evolvability, and neutrality

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Evolvability as a function of purifying selection in TEM-1 β-lactamase. (2015, positive): “…observed at nearly all levels of biological organization, from protein structure and function (McLaughlin et al., 2012; Rennell et al., 1991; Suckow et al., 1996) to metabolic flux (Kacser and Burns, 1981) to regulation of gene expression (Wagner, 2005a) to development (Waddington, 1942, 1953).”
Global Optimization Algorithms -- Theory and Application (2009, background): “Wagner [97; 98] points out that this word has two uses in biology.”
Backbone flexibility in computational protein design. (2009, background): “Proteins exploit this robustness [58] to accumulate sequence changes allowing them to vary and expand their”
Stability effects of mutations and protein evolvability. (2009, background): “Stability margins and environmental robustness The higher stability is above DGt (higher negative DG values), the higher is the protein’s tolerance to mutations, or neutrality (genetic robustness is another oft-used term) [4 ,42,43,44].”
Enzyme promiscuity: a mechanistic and evolutionary perspective. (2010, background): “In the absence of tRNA, the aminoacyl-AMP intermediate reacts aminoacyl-tRNA synthetases bind DNA or mRNA and thus regulate transcription, splicing, and translation, or they act as cofactors in RNA traf-ﬁcking (51).”