Extensive Cortical Rewiring after Brain Injury

By N. Dancause, S. Barbay, S. Frost, E. Plautz, Daofen Chen, E. Zoubina, Ann M. Stowe, R. Nudo. Journal of Neuroscience, 2005

728 citations recorded by the source corpus.

Previously, we showed that the ventral premotor cortex (PMv) underwent neurophysiological remodeling after injury to the primary motor cortex (M1). In the present study, we examined cortical connections of PMv after such lesions. The neuroanatomical tract tracer biotinylated dextran amine was injected into the PMv hand area at least 5 months after ischemic injury to the M1 hand area. Comparison of labeling patterns between experimental and control animals demonstrated extensive proliferation of novel PMv terminal fields and the appearance of retrogradely labeled cell bodies within area 1/2 of the primary somatosensory cortex after M1 injury. Furthermore, evidence was found for alterations in the trajectory of PMv intracortical axons near the site of the lesion. The results suggest that M1 injury results in axonal sprouting near the ischemic injury and the establishment of novel connections within a distant target. These results support the hypothesis that, after a cortical injury, such as occurs after stroke, cortical areas distant from the injury undergo major neuroanatomical reorganization. Our results reveal an extraordinary anatomical rewiring capacity in the adult CNS after injury that may potentially play a role in recovery.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Epidemiology

View Paper: https://www.semanticscholar.org/paper/bd5e27523311ddd777fa485a70f217681609ca2d

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Citations in the corpus

Activation likelihood estimation meta-analysis of motor-related neural activity after stroke (2012, background): “Evidence from animal models indicates that both areas support the function of the affected motor network and thereby contribute to reorganization after stroke (Aizawa et al., 1991; Dancause et al., 2005; Eisner-Janowicz et al., 2008; Schmidlin et al., 2008).”
The Science of Neural Interface Systems (2009, neutral): “…is surprising because a variety of animal and indirect human studies suggest that the motor cortex can reorganize rapidly in response to injury (Dancause et al. 2005, Donoghue et al. 1990, Giraux et al. 2001, Nudo 2006, Sanes et al. 1990), which apparently has not occurred in similar form in…”
Training-induced structural changes in the adult human brain. (2008, background): “Further, corresponding to learning-induced anatomical connectivity changes, local motor cortex lesions followed by functional recovery showed in a tracing study the occurrence of new connections from the ventral premotor area reaching the damaged area and further projecting to somatosensory cortex i”
Cellular and molecular mechanisms of neural repair after stroke: Making waves (2006, background): “In nonhuman primates, poststroke axonal sprouting extends new connections from premotor cortex to primary sensory cortex, in some cases, over distances of up to 1cm.(25) The pattern of poststroke axonal sprouting in experimental animals resembles the pattern of cortical remapping in human stroke ima”
Experience-dependent structural synaptic plasticity in the mammalian brain (2009, background): “Structural plasticity might also be involved in recovery from brain injur”
The Neural Architecture of the Language Comprehension Network: Converging Evidence from Lesion and Connectivity Analyses (2011, background): “Reorganization of the architecture of functional networks is a key factor for the recovery of function following neurological injury, and this process might be mediated by the connections that allow intact regions to acquire new functions and enable the surviving sections of damaged regions to be re”
A Neurovascular Niche for Neurogenesis after Stroke (2006, methodology): “x–y coordinate of every DCX cell was converted into an equivalent polar coordinate (Carmichael et al., 2001; Dancause et al., 2005) (r, )”
Evidence for potentials and limitations of brain plasticity using an atlas of functional resectability of WHO grade II gliomas: Towards a "minimal common brain" (2011, background): “Note that for these areas, even biological plasticity –which has been shown to offer an axonal rewiring in animal models (Dancause et al., 2005; Guleria et al., 2008) – would fail on the long term to repair the connectivity required to rebuild an effective network topology, hence a functional…”
Dynamic functional reorganization of the motor execution network after stroke. (2010, background): “For example, a previous study on animals has demonstrated increased connections from the ventral premotor cortex to the somatosensory cortex in a monkey with an ischaemic lesion to motor cortex (Dancause et al., 2005).”
Dynamic causal modeling of cortical activity from the acute to the chronic stage after stroke (2011, neutral): “Invasive tract tracing studies in macaques showed that both vPMC and SMA have extensive projections toM1and, therefore,mightplayan important role inmotor recovery, for example, by facilitating the motor output of M1 neurons through corticocortical projections (Dancause et al., 2005; Dumand Strick, 2”