Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals.

By H. Chow, Yan Cai, I. Hakim, J. Crowell, Farah Shahi, Christine A. Brooks, R. Dorr, Y. Hara, D. Alberts. Clinical Cancer Research, 2003

708 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bd570dfb36493034130f390d734058077e9d78db

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Citations in the corpus

Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas (2006, background): “(ii) Multi-dose oral consumption of EGCG and a concentrated green tea extract (Polyphenon E) by 40 healthy human volunteers at a daily dose of 800 mg ECGC (equivalent in EGCG content of 8-16 cups of green tea) for up to 4 wk was safe and well-tolerated [130] [131] [132] .”
Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. (2006, background): “Nonetheless, it is quite relevant to our understanding of the overall in vivo effects of green tea consumption, given the low oral bioavailability of the polyphenolic catechins after drinking green tea (Chow et al., 2001, 2003).”
The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention (2010, background): “Additionally, the concentrations of tea catechins used in these studies exceed those available in vivo following tea consumption [69].”
Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives. (2006, background): “A separate clinical study found that daily oral administration of either 400 or 800 mg of EGCG did not protect against UV-induced erythema (Chow et al., 2003).”
Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice (2005, unknown): “Based on a previous safety and pharmacokinetic study, it is likely that a daily 1500 – 1600 mg bolus of EGCG in humans will approximately achieve levels similar to those in sera of EGCG (20 mg/kg) intraperitoneally injected mice (Chow et al., 2003).”
Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. (2006, background): “or Polyphenon E, a defined, decaffeinated green tea polyphenols mixture with a composition very similar to our GTCs preparation (28).”