The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention
By J. Lambert, R. Elias. Archives of Biochemistry and Biophysics, 2010
868 citations recorded by the source corpus.
Green tea (Camellia sinensis) is rich in catechins, of which (−)-epigallocatechin-3-gallate (EGCG) is the most abundant. Studies in animal models of carcinogenesis have shown that green tea and EGCG can inhibit tumorigenesis during the initiation, promotion and progression stages. Many potential mechanisms have been proposed including both antioxidant and pro-oxidant effects, but questions remain regarding the relevance of these mechanisms to cancer prevention. In the present review we will discuss the redox chemistry of the tea catechins and the current literature on the antioxidant and pro-oxidative effects of the green tea polyphenols as they relate to cancer prevention. We report that although the catechins are chemical antioxidants which can quench free radical species and chelate transition metals, there is evidence that some of the effects of these compounds may be related to induction of oxidative stress. Such pro-oxidant effects appear to be responsible for the induction of apoptosis in tumor cells. These pro-oxidant effects may also induce endogenous antioxidant systems in normal tissues that offer protection against carcinogenic insult. This review is meant point out understudied areas and stimulate research on the topic with the hope that insights into the mechanisms of cancer preventive activity of tea polyphenols will result.
Subfields: Applied Microbiology and Biotechnology, Biochemistry, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/eda4ea68e57c27b000bfbf59f380272e8b3a921a
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Citations in the corpus
- Multivariate Analysis Based on GC-MS Fingerprint and Volatile Composition for the Quality Evaluation of Pu-Erh Green Tea (2015, background): “In these different types of tea, green tea is a kind of non-fermented tea and represents 20 % of world consumption particularly in Asian countries like China, Korea, and Japan (Lambert and Elias 2010).”
- The Immunomodulatory and Anti-Inflammatory Role of Polyphenols (2018, background): “conditions such as superoxide leakage [196].”
- Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects (2016, background): “It was for example shown that some extracted polyphenols in high concentrations act even in the opposite way: instead of preventing cancer they can contribute to its formation and progression [4,16,17].”
- Beneficial Properties of Green Tea Catechins (2020, background): “Inhibition of the mitogen-activated protein kinases (MAPKs), ERK, JNK, and p38 is implicated in many patho-physiological processes, such as cell proliferation, differentiation, and cancer cell death [39,46].”