The microenvironment of the tumour–host interface

By L. Liotta, E. Kohn. Nature, 2001

2,380 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/bd32f9f357633f373ec0a463682029ca3ed82bfb

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In Immunology and Allergy

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Citations in the corpus

Axis of evil: molecular mechanisms of cancer metastasis (2003, background): “The principal classes of enzymes that degrade the ECM- and cellassociated proteins are (Werb, 1997; Liotta and Kohn, 2001): (1) the matrix metalloproteinases (MMPs), a family of membrane-anchored and -secreted proteinases; (2) tissue serine proteinases, including urokinase plasminogen activator,…”
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. (2006, background): “The prevailing view is that geno/phenotypes that meet all requirements for metastasis are a rare occurrence in a primary tumor, in agreement with the observed inefficiency of metastasis (Liotta and Kohn, 2003).”
Tumor-stroma ratio is an independent predictor for survival in early cervical carcinoma. (2014, background): “For instance, the principal enzymes that are needed in invasion, including the matrix metalloproteinases (MMPs), the adamalysin-related membrane proteinases and tissue serine proteinases, are contributed by host stroma cells, not by the invading tumor cells [15].”
Three-dimensional multispecies nonlinear tumor growth--I Model and numerical method. (2008, background): “Also, the microenvironment of invasive tumors may be characterized by nonsharp boundaries between tumor and host tissues, and between multiple species within a tumor (Liotta and Kohn, 2001; Lamszus et al., 2003; Kunkel et al., 2001).”
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. (2006, background): “It is becoming increasingly clear that tumorigenesis in vivo involves not just the biology of the tumor cell itself, but rather a complex interplay between tumor cells and the deregulation of normal host physiological functions that ultimately aid in tumor progression (Tlsty and Hein, 2001; Liotta a”
Role of tissue stroma in cancer cell invasion (2003, background): “The concept that the microenvironment is crucial for the maintenance of cellular functions and tissue integrity suggests that a cancer-induced change in the stroma may contribute to cancer invasion [17].”
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “The composition and structure of the normal interstitium (50, 91, 147, 216, 246, 374) and that of tumors (93, 230, 231, 273, 282, 303, 444) have been covered in several extensive reviews and are thus only briefly described here.”
The tumor microenvironment. (2012, background): “Instead, there is a bidirectional, dynamic, very intricate interaction between the cells of the stromal tissue and the cancer cells [21].”