Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

By Elizabeth H Blackburn, C. Greider, J. Szostak. Nature Medicine, 2006

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The hallmarks of aging. (2013, background): “The genomic stability systems also include specific mechanisms for maintaining the appropriate length and functionality of telomeres (which are the topic of a separate hallmark, see below), and for ensuring the integrity of mitochondrial DNA (mtDNA) (Blackburn et al., 2006; Kazak et al., 2012).”
Alternative lengthening of telomeres: models, mechanisms and implications (2010, background): “Telomeric DNA has a repetitive G-rich sequence (for example, in all vertebrates the sequence is 5′-TTAGGG-3′) that can be synthesized de novo by a reverse transcriptase enzyme, telomerase”
Biological Age Predictors (2017, background): “Telomeres are repetitive DNA sequences capping chromosomes, which shorten every time cells divide; thus, telomere length is a popular marker of biological aging (Blackburn et al., 2006).”