Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

By A. Skardal, T. Shupe, A. Atala. Drug Discovery Today, 2016

457 citations recorded by the source corpus.

In recent years, advances in tissue engineering and microfabrication technologies have enabled rapid growth in the areas of in vitro organoid development as well as organoid-on-a-chip platforms. These 3D model systems often are able to mimic human physiology more accurately than traditional 2D cultures and animal models. In this review, we describe the progress that has been made to generate organ-on-a-chip platforms and, more recently, more complex multi-organoid body-on-a-chip platforms and their applications. Importantly, these systems have the potential to dramatically impact biomedical applications in the areas of drug development, drug and toxicology screening, disease modeling, and the emerging area of personalized precision medicine.

Subfields: Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/e460444a8b16ab08bd2ea13c86fd58af328f463f

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In Biomedical Engineering

1. Navid Kashaninejad
2. Trond Kvamsdal
3. Omer San
4. Adil Rasheed
5. Nam-Trung Nguyen

Citations in the corpus

• Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture (2018, background): “In fact, several previous works have suggested that 2D-monolayer cell cultures should be replaced with multicellular tumor spheroids that better recapitulate the in-vivo environment [5-9].”
• Digital Twin: Values, Challenges and Enablers From a Modeling Perspective (2019, background): “[12] gives the progress made in this direction.”