Serine, glycine and one-carbon units: cancer metabolism in full circle

By Jason W. Locasale. Nature Reviews. Cancer, 2013

1,529 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bbf6606ce89ec24509b3460d6267a51a273fdff1

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Citations in the corpus

From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy (2016, neutral): “BPTES inhibition of hGA(124-551), a truncated form of human kidneytype glutaminase.”
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism (2015, background): “Many cancers are vulnerable to disruptions in one-carbon metabolism (Locasale, 2013), and our results demonstrate the necessity of methionine metabolism for the maintenance of histone methylation and the consequences for expression of oncogenic programs.”
MYC, Metabolism, and Cancer. (2015, background): “In addition to glucose and glutamine, de novo synthesis of nucleotides also requires folate as a cofactor for various enzymatic steps (121).”
Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, background): “In addition to aspartate, alanine and phosphoserine can be generated via the enzymes GPT and PSAT by use of nitrogens provided by glutamine (Figure 4a) (67, 68).”
ROS homeostasis and metabolism: a dangerous liason in cancer cells (2016, background): “, ME1, IDH1, PPP and glutaminolysis) has received significant attention(1,102) with particular emphasis on the role of one-carbon metabolism.(113) With this respect, mitochondrial NADPH mainly derives from serine”
T cell metabolism drives immunity (2015, background): “…the role of one-carbon metabolism in generating units for nucleic acid synthesis from folate has long been appreciated, it was more recently recognized that this pathway is an important source of NADPH to maintain redox balance and methyl groups for methylation (Locasale, 2013; Fan et al., 2014).”
Mitochondria and Cancer (2016, neutral): “(Locasale, 2013).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “Moreover, other nutrient sources, including threonine, choline, betaine, dimethylglycine, and sarcosine (N-methylglycine), regulate methylation reactions via their convertion into glycine (Wang et al., 2009; Locasale, 2013).”