CD1d-restricted and TCR-mediated activation of V α14 NKT cells by glycosylceramides

By 河野 鉄. 2000

803 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/bbe1fdc31c1791e4479bde921cb0d637b7c857e7

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In Immunology

1. M. Kronenberg
2. M. Smyth
3. D. Godfrey
4. L. Gapin
5. A. Bendelac
6. J. Trapani
7. L. Teyton
8. M. Brenner

Citations in the corpus

• Induction of Regulatory Properties in Dendritic Cells by Vα14 NKT Cells1 (2005, background): “The invariant Ag receptors recognize glycolipid Ags, including -galactosylceramide ( -GalCer)(4) (1), presented by CD1d (2).”
• Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells (2000, positive): “Perhaps the strongest implication for a role for NKT cells in Th1 immunity is in tumor rejection responses after exogenous IL-12 (9, 28–30) or a -GalCer (11, 31) administration.”
• Going both ways: immune regulation via CD1d-dependent NKT cells. (2004, neutral): “noma, thymoma, carcinoma, and sarcoma (17, 87, 89).”
• The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs1 (2003, background): “Although the physiological ligand(s) remain unknown for CD1d, a synthetic glycolipid, -galactosylceramide ( GC)(3) has been shown to selectively activate NKT cells expressing the V 14/V 8 TCR (10).”
• The biology of NKT cells. (2007, background): “Thus, mVα14 and hVα24 NKT cells, irrespective of their Vβ-Dβ-Jβ chain usage, recognize a marine sponge–derived α-galactosylceramide (αGalCer) (21, 22) and closely related microbial α-glycuronylceramides (23–25), as well as the self antigen isoglobotrihexosylceramide (iGb3) (26).”
• Cutting Edge: Analysis of Human Vα24+CD8+ NK T Cells Activated by α-Galactosylceramide-Pulsed Monocyte-Derived Dendritic Cells (2002, methodology): “The details of PCR primers and J Q probe sequences and PCR conditions were described elsewhere (13).”
• The unconventional lifestyle of NKT cells (2002, background): “and they have a strong response to the glycosphingolipid α-galactosyl ceramide (α-GalCer; see Box 1 ) presented by CD1”
• Vα24-JαQ-Independent, CD1d-Restricted Recognition of α-Galactosylceramide by Human CD4+ and CD8αβ+ T Lymphocytes1 (2002, background): “These NKT specifically recognize the marine-sponge-derived, synthetic glycolipid GC, while the natural ligand seen by these cells in vivo remains unknown (5).”