The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs1

By C. Cantu, K. Benlagha, P. Savage, A. Bendelac, L. Teyton. Journal of Immunology, 2003

85 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/e46bd434701d4dc9c105afd958874ce2faf203e2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Bendelac
2. L. Teyton
3. P. Savage
4. M. Kronenberg

Citations in the corpus

• The biology of NKT cells. (2007, background): “The affinity of interaction between CD1d-αGalCer and mouse TCRs is one of the highest ever recorded for natural TCR/ligand pairs with a Kd ∼100 nM, owing to a slow off rate, for several Vα14-Jα18/Vβ8 combinations examined (50, 51) and may be significantly lower in the human system (∼7 μM) (52).”