The gut microbiome in atherosclerotic cardiovascular disease

By Zhuye Jie, Huihua Xia, Shi-long Zhong, Q. Feng, Shenghui Li, Suisha Liang, Huanzi Zhong, Zhipeng Liu, Yuan Gao, Hui Zhao and 32 more. Nature Communications, 2017

1,375 citations recorded by the source corpus.

The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases. The gut microbiota may play a role in cardiovascular diseases. Here, the authors perform a metagenome-wide association study on stools from individuals with atherosclerotic cardiovascular disease and healthy controls, identifying microbial strains and functions associated with the disease.

Subfields: Molecular Biology, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/bbbdec858cf2aa4e8dc28515da9ceed20fc5f668

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Citations in the corpus

A Novel Sparse Compositional Technique Reveals Microbial Perturbations (2019, neutral): “Previous studies (34, 35) have also reported changes in these taxonomic classes in cardiometabolic comorbidities of sleep apnea, which suggests that our method potentially guides biologically relevant observations.”
The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health (2020, background): “Cardiovascular atherosclerosis cardiovascular disease (50)”
Atherosclerosis: Recent developments (2022, background): “Epidemiological studies have revealed strong associations between the composition of the gut microbiota and numerous diseases, including CAD, but the causal relationships are largely unknown (Jie et al., 2017).”
Factors affecting the composition of the gut microbiota, and its modulation (2019, neutral): “, 2017), cardiovascular disease (Cui et al., 2017b; Jie et al., 2017; Trøseid, 2017), hypertension (Li et al.”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Emerging research reports bacterial DNA in blood associated with a personal microbiota fingerprint as a predictor of cardiovascular events and stool microbiome as a signature of cardiovascular disease (358, 359).”
Human gut microbiota in health and disease: Unveiling the relationship (2022, background): “Moreover, an increased abundance of Streptococcus and Enterobacteriaceae is linked with coronary artery disease (Jie et al., 2017).”