A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.

By N. Lee, Young Geum Choi, Jieun Baik, Songyi Han, D. Jeong, Y. Bae, Nacksung Kim, Soo Young Lee. Blood, 2005

918 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bb902a79deade24f20b8f0bcf8709b58c6d314a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. David I. Brown
2. K. Griendling
3. S. Dikalov
4. Rhian M. Touyz
5. E. Schiffrin

In Molecular Biology

1. J. H. Park
2. Soo Young Lee
3. David I. Brown
4. S. Manolagas
5. K. Griendling
6. N. Lee
7. S. Khosla
8. R. Jilka

Citations in the corpus

• From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. (2010, background): “Estrogens and androgens, acting via their respective receptors (ER and AR), attenuate both osteoclastogenesis and survival by stimulating GSH and Trx reductase in an ERK-dependant manner (113, 145, 172, 176, 177).”
• Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “Dietary supplementation with N-acetylcysteine is able to completely block bone loss associated with ovariectomy in rodents (Lean et al., 2003; Lee et al., 2005), and also shows some beneficial effects in slowing bone resorption in early post-menopausal women (Sanders et al., 2007).”
• Redox regulation of FoxO transcription factors (2015, background): “Both RANKL and M-CSF increase the levels of ROS in osteoclast progenitors and potentiate osteoclast formation and activation [283,284].”
• Nox proteins in signal transduction (2009, positive): “Nox1 mRNA is most highly expressed in colon epithelia [48], but is also expressed at lower levels in VSMCs, endothelial cells, uterus, placenta [80], prostate, osteoclasts [81], retinal pericytes, neurons, astrocytes and microglia [26].”
• Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation (2017, background): “Lee et al. (2005) reported that the reactive oxygen species produced by the RANK-TRAF6-Rac1-NADPH oxidase 1-dependent pathway are also required for MAPK activation and osteoclastogenesis.”
• Osteoimmunology: interplay between the immune system and bone metabolism. (2006, background): “Recent reports suggest that ROS act as a key second messenger during osteoclastogenesis (81), such that TRANCE stimulation induces the production of ROS in OC precursors via the small GTPase Rac1 and the ROSinducing factor NADPH oxidase (Nox) 1.”
• The Oxygen Rich Postnatal Environment Induces Cardiomyocyte Cell Cycle Arrest Through DNA Damage Response (2014, neutral): “…continued on next page) 568 Cell 157, 565–579, April 24, 2014 ª2014 Elsevier Inc. zebrafish heart and the early neonatal mouse heart and outline the time frame of the metabolic switch from anaerobic glycolysis tomitochondrial oxidative phosphorylation inmouse heart within one week after birth.”