Postsynaptic Receptor Trafficking Underlying a Form of Associative Learning

By Simon Rumpel, Joseph E LeDoux, Anthony M. Zador, R. Malinow. Science, 2005

802 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/bb6baeb9afaea2a8de8fe04a20c9acc90b6d3bce

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Y. Dudai
2. E. Kandel
3. Giulio Tononi
4. K. Tye
5. Chiara Cirelli
6. Denis Paré
7. M. Mayford
8. T. Takeuchi

In Cognitive Neuroscience

1. Y. Dudai
2. Giulio Tononi
3. E. Kandel
4. Chiara Cirelli
5. K. Tye
6. Denis Paré
7. M. Mayford
8. T. Takeuchi

In Neurology

1. K. Tye
2. Y. Dudai
3. Giulio Tononi
4. Denis Paré
5. Richard G. M. Morris
6. Andreas Lüthi
7. S. Siegelbaum
8. M. Mayford

Citations in the corpus

• Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration (2014, background): “…and Barth, 2006), association learning (Gruart et al., 2006), contextual memory formation (Hu et al., 2007), fear conditioning (Matsuo et al., 2008; Rumpel et al., 2005), visual perceptual learning (Sale et al., 2011), cue-reward learning (Tye et al., 2008), and avoidance learning (Whitlock et…”
• Neural Circuit Motifs in Valence Processing (2018, positive): “both negative and positive associations (Clem and Huganir, 2010; McKernan and Shinnick-Gallagher, 1997; Rogan et al., 1997; Rumpel et al., 2005; Tye et al., 2008).”
• AMYGDALA MICROCIRCUITS CONTROLLING LEARNED FEAR (2014, background): “Indeed, even in brain slices kept in vitro, where afferent auditory axons to LA are cut from the somata contributing them, the efficacy of auditory synapses is enhanced after fear conditioning (McKernan and Shinnick-Gallagher , 1997; Rumpel et al., 2005).”
• Synapses and memory storage. (2012, background): “Moreover, similar to mechanisms of NMDA receptor–dependent LTP, learned fear requires the enhanced trafficking of AMPA receptors to the synapses of amygdala neurons (Rumpel et al. 2005).”
• Amygdala inhibitory circuits and the control of fear memory. (2009, background): “In classical fear conditioning, the subject is exposed to a noxious unconditioned stimulus (US), such as a foot-shock, in conjunction with a neutral conditioned stimulus (CS), such as a tone or a light.”
• Dendritic calcium spikes induce bi-directional synaptic plasticity in the lateral amygdala. (2007, positive): “Whereas LTP at thalamic afferents is induced and expressed postsynaptically (Weisskopf et al., 1999; Bissière et al., 2003; Humeau et al., 2005; Rumpel et al., 2005; but see: McKernan and Shinnick-Gallagher, 1997), LTP induction at cortical afferents involves both pre-and postsynaptic mechanisms…”
• The synaptic plasticity and memory hypothesis: encoding, storage and persistence (2014, background): “In the light of an estimate of the number of amygdala neurons required for learned fear expression [20], the distributed nature of hippocampal circuitry suggests that these changes in rectification may also have been expressed in a subset of neurons.”