Synapses and memory storage.

By M. Mayford, S. Siegelbaum, E. Kandel. 2012

500 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Learning to Remember: A Synaptic Plasticity Driven Framework for Continual Learning (2019, background): “First, it is very much against the notion of bio-inspired design, as natural brains do not feature the retrieval of information identical to originally exposed impressions [15].”
Multi-electrode array technologies for neuroscience and cardiology. (2013, background): “A great deal of neuroplasticity is associated with changes in the amplitude of synaptic potentials 13 .”
Structural Components of Synaptic Plasticity and Memory Consolidation. (2015, background): “Although a number of technical hurdles remain, the continuing improvements in optical and molecular approaches raise hope that the ability to visualize, in real time, the synaptic changes that mediate the flow and storage of information in specific neural circuits will come to fruition in the not-to”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, unknown): “…and the early-LTP (ELTP), which are transcription and translation independent and last for about 1e2 h, and the late LTP (L-LTP), which may last for hours to days and depend on transcription and translation activity (CostaMattioli et al., 2009; Malenka and Bear, 2004; Mayford et al., 2012).”
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012, background): “…complete understanding of the mechanisms underlying LTP and LTD will continue to contribute to our understanding of the mechanisms of learning and memory (see Mayford et al. 2012), as well as provide insight into the pathophysiology of a broad spectrum of brain diseases (see Sheng et al. 2012).”
How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory (2019, background): “A fundamental difference between short-term memory lasting minutes and long-term memory (LTM) lasting days to weeks or longer is that LTM requires de novo protein synthesis and structural changes in neurons (Davis and Squire 1984; Kandel 2001; Mayford et al. 2012).”