Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit

By L. Vermeulen, G. D. Wilde, Sofie Notebaert, W. Vanden Berghe, G. Haegeman. 2002

307 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/bb1cb6d39faa09ab45a669343eef54596b8facba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. H. Nakano
2. Lin-Feng Chen
3. W. Greene
4. Robert F. Schwabe
5. N. Perkins
6. S. Ghosh
7. M. Hayden

In Immunology

1. H. Nakano
2. Lin-Feng Chen
3. W. Greene
4. Robert F. Schwabe
5. N. Perkins
6. S. Ghosh
7. M. Hayden

Citations in the corpus

• Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury (2008, unknown): “To determine whether mutations of TLR4, TRIF, or TRAF6 affect NF-kB activation, we performed in situ signaling experiments to detect nuclear accumulation of Ser276-phosphorylated NF-kBp65 indicative of NF-kB activation (Vermeulen et al., 2002).”
• Shaping the nuclear action of NF-κB (2004, background): “In the absence of these modifications, NF-κB displays significantly impaired transcriptional activit”
• IKKβ phosphorylates p65 at S468 in transactivaton domain 2 (2005, background): “In recent years, it has been suggested that the phosphorylation of NF-κB subunits represents a second mechanism by which NF-κB transcriptional activity is regulated (1, 6, 7 , 26).”
• Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import 1 (2004, background): “Once activated, inducible posttranslational modifications including acetylations and phosphorylations allow the regulation of NF- B transcriptional activity (20, 21).”
• Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids (2005, background): “p65-p50 heterodimer) [figure 1] and Nongenomic mechanisms are characterised by a AP-1 (Fos-Jun heterodimer).[147,148] In later phases rapid onset of effect (<15 minutes) because no time of inflammation, NF-κB might also play a role in the is necessary for gene transcription and translation.”