HIF-1: upstream and downstream of cancer metabolism.
By G. Semenza. Current Opinion in Genetics and Development, 2010
1,364 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/baf90f70cc080f36598c35689b8ad61b4bfb2ad2
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Gabriele Multhoff
- G. Brooks
- Yongqian Shu
- Kay F Macleod
- Ke Wei
- Xinming Jing
- David M. Sabatini
- Jiangwen Zhang
In Molecular Biology
- Arkaitz Carracedo
- P. Pandolfi
- David M. Sabatini
- J. Cantor
- Kay F Macleod
- Danielle Glick
- Sandra Barth
- G. Brooks
Citations in the corpus
- Hallmarks of cancer: the next generation. (2011, neutral): “…can be further accentuated under the hypoxic conditions that operate within many tumors: the hypoxia response system acts pleio-tropically to upregulate glucose transporters and multiple enzymes of the glycolytic pathway (Semenza, 2010a; Jones and Thompson, 2009; DeBerardinis et al., 2008).”
- Autophagy: cellular and molecular mechanisms (2010, background): “As mentioned, hypoxia also activates autophagy [77] through effects that are both dependent on target genes induced by hypoxia-inducible factor (HIF) [77] and also through HIF-independent effects that are likely mediated through TOR inhibition downstream of AMPK, REDD1 and Tsc1/Tsc2 [74,78].”
- Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “Also, whether cancer stem cells preferentially exist in tumor hypoxic regions needs confirmation [109].”
- KRAS: feeding pancreatic cancer proliferation (2014, neutral): “The hypoxia-dependent regulation of metabolism is a principal and elemental function of the hypoxia-inducible factor 1 alpha (HIF-1α) transcriptional activator [38].”
- SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization (2011, background): “Metabolic reprogramming in cancer cells is regulated by several oncogenic cues, including the PI3K/Akt, Myc, or hypoxia-inducible factor (HIF) pathways that serve to increase glucose uptake, glycolysis, angiogenesis, and stress resistance (Kaelin and Ratcliffe, 2008; Semenza, 2010; Tennant et al., 2”
- The Role of Autophagy in Cancer: Therapeutic Implications (2011, background): “Autophagy is induced in hypoxic tumor cells from regions that are distal to blood vessels, and HIF-1a-dependent and -independent activation have been described (21).”
- The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance (2011, background): “Moreover, autophagy is an adaptive prosurvival pathway in response to hypoxic conditions (Semenza, 2010).”
- Revisiting the Warburg effect: historical dogma versus current understanding (2020, background): “…by glycolytic intermediates, (h) interactions with the hostile TME and cancer-associated stromal cells, and (i) maintenance of the pHi–pHe gradient (Semenza, 2010; Cantor & Sabatini, 2012; Martinez-Pastor & Mostolavsky, 2012; Faubert et al. 2013; Lu et al. 2015; Tran et al. 2016; He et al.…”
- The Science and Translation of Lactate Shuttle Theory. (2018, background): “Further, the master transcription factor involved in tumor cell glycolysis, HIF-1, has been shown to be activated by lactate in different cancer lines (De Saedeleer et al., 2012; Lu et al., 2002; Semenza, 2010).”