Analysis of islet inflammation in human type 1 diabetes

By A. Willcox, S. Richardson, A. Bone, A. Foulis, N. Morgan. Clinical and Experimental Immunology, 2009

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Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases (2010, positive): “A histological study of islets that were isolated from patients with new-onset type 1 diabetes immediately post-mortem found that FOXP3 + T cells were only rarely present in the islets; this is consistent with the idea that there are inadequate numbers of T Reg cells in the islets of individuals w”
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients (2012, background): “Our histopathological assessment shows many parallels with the recent-onset cohort that was recently revisited (Willcox et al., 2009), and the infiltrating CD8 T cells may thus bear relevance in the protracted effector phase that on some occasions characterizes the course of T1D after clinical…”
Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. (2011, background): “a recent study it was shown that in this disease, also, individual islets may still contain a considerable number of insulin-containing cells (410).”
The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives (2018, background): “This was further depicted in human studies using pancreas samples obtained post mortem from subjects diagnosed with recent-onset T1D.(27,38)”