Membranes are more mosaic than fluid

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Biophysical dissection of membrane proteins (2009, background): “It is also useful for describing the interactions between proteins in the crowded membrane environmen”
Biotechnology Applications of Tethered Lipid Bilayer Membranes (2012, background): “From hosting transmembrane proteins involved in signal transduction pathways to regulating what enters and exits a cell, phospholipid membranes represent a critically important interface within biological systems [1–4].”
High-resolution atomic force microscopy and spectroscopy of native membrane proteins (2011, background): “However, it turned out over the past decades that membranes are ‘more mosaic than fluid’ [287].”
Emerging roles for lipids in shaping membrane-protein function (2009, background): “Engelman, D. M. Membranes are more mosaic than fluid. Nature 438, 578–580 (2005). 2. Sukharev, S. I. et al. Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL. J. Gen. Physiol. 113, 525–540 (1999). 3. Perozo, E. et al. Physical principles un”
Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins (2015, background): “The ratio of protein to lipid in cellular membranes has been approximated to be 1:40 by number [3], suggesting that the membrane may in fact be crowded with proteins [4, 5].”