c-Myc-regulated microRNAs modulate E2F1 expression

By Kathryn A. O’Donnell, Erik A. Wentzel, K. Zeller, C. V. Dang, Joshua T. Mendell. Nature, 2005

3,046 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ba044612bfb7ebdb20b1d37622569d56d31e5250

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Citations in the corpus

Myc's broad reach. (2008, background): “In addition, the apparently nonproductive binding sites for Myc may regulate transcription of genes not normally included on expression arrays, such as those encoding miRNAs (He et al. 2005; O’Donnell et al. 2005; Chang et al. 2008; Schulte et al. 2008) or RNA polymerase III transcripts (Gomez-Roman”
Double-hit B-cell lymphomas. (2011, neutral): “Johnson et al15 2009 54/54 (100) 20/54 (46) 62 (24-93) 41/54 (76) 27/54 (50) 32/45 (71)§ NA 19/54 (35) 38/54 (70)”
A MicroRNA Signature of Hypoxia (2006, background): “Another transcription factor, the c-myc oncogene product, was also found to activate the expression of a microRNA cluster (25).”
Genomics of microRNA. (2006, background): “Some other miRNAs, such as the miR-17w92 cluster, have oncogenic potential [ 48 ,104], as demonstrated by a transgenic study where enforced expression of the miR- 17w92 cluster induced B-cell lymphoma when coexpressed with c-myc.”
MicroRNAs in human cancer. (2013, background): “Examples include the TP53 regulated mir-34a [57, 58], the RAS regulated mir-21 [33, 59, 60] and the MYC regulated mir-17-92 gene cluster [61, 62].”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Recently, it was demonstrated that the inhibition of two miRNAs in this cluster, miR-17-5p and miR-20a, sensitized lung cancer cells to apoptotic insults (Matsubara et al., 2007), which suggests that these miRNAs may be useful as a potential therapeutic modality. miR-20a negatively regulates E2F1 (O”