Collagen sponges for bone regeneration with rhBMP-2.

By M. Geiger, R. H. Li, W. Friess. Advanced Drug Delivery Reviews, 2003

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Collagen-hydroxyapatite composites for hard tissue repair. (2006, background): “The current aim of the biological implant is to be indistinguishable from the surrounding host bone (Geiger et al., 2003).”
Biodegradable Materials for Bone Repair and Tissue Engineering Applications (2015, background): “002–5 3 2–4 1–4 Carriers (sponges) for BMP [61–63], composite with HA [64], membranes for GBR [65,66], scaffolds [67]”
Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends (2007, background): “On the other hand, growth factors and other active agents can be combined with collagen-based systems, including scaffolds and gels to prolong their release rate and increase their therapeutic effect on tissue engineering approaches (Geiger et al .”
Current development of biodegradable polymeric materials for biomedical applications (2018, background): “Prolonged release of bioactive proteins, such as recombinant human bone morphogenic protein-2 (rhBMP-2), have been reported when utilized in conjunction with collagen matrices due to desirable interactions of the collagen matrix with the protein.(30) This combination product is approved”